Effects of Ethanol on Neurotransmitter Systems.

Lecturer
Dr. Tom Dunwiddie
Department of Pharmacology (C2366)
University of Colorado HSC
4200 East 9th Ave.
Denver, CO 802662
(303) 315-4222
tom.dunwiddie@uchsc.edu

Editor
Dr. Paula Hoffman
Department of Pharmacology
University of Colorado School of Medicine, (C-236)
4200 East 9TH Ave
Denver, CO 80262
(303) 315-5690
paula.hoffman@uchsc.edu

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Lecture Summary

Pre-synaptic effects - modulation of release
1. Via actions on Ca++ channels
2. Interactions with transmitter release mechanisms
Post-synaptic effects
1. Direct interactions of ethanol with ligand-gated ion channels
  1. Direct allosteric effects
    1. Enhancement of some ion channels
    2. Antagonism of some ion channels
    3. Evidence for a direct modulatory effect
    4. Alkanol "cut-off" effects
  2. Indirect allosteric effects on ion channels (release of neurosteroids)
2. Indirect interations of ethanol with ligand-gated ion channels
  1. Effects upon protein kinases
  2. Possible actions on cytoskeleton.
3. Interactions of ethanol with neurotransmitter effector mechanisms
  1. Ethanol effects on adenylyl cyclase.
  2. Ethanol effects on protein kinases.